Here is a best practice guide on WindowsSecurtiy.com on how to install and configure bitlocker. If you have a laptop and have Vista installed, it is not a bad idea to install BitLocker and get it configured and running. If your laptop was ever stolen you could breathe a little easier knowing that data was protected.
The second part to this guide will cover off configuring BitLocker from Active Directory and to manage BitLocker in terms of key recovery.